Universitätsklinik für Kardiologie
 
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Universitätsklinik für Kardiologie / Mitarbeiter
 
 
Prof. Dr. med. Axel Linke / Publikationen
 
ERST- und SENIORAUTORENSCHAFTEN
 
Eitel I, Stiermaier T, Rommel KP, Fürnau G, Sandri M, Mangner N, Linke A, Erbs S, Lurz P, Boudriot E, Mende M, Desch S, Schuler G, Thiele H
Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial.
Eur Heart J 2015; 36(44): 3049-3057
ISSN 0195-668X
 
Bosmans J, Bleiziffer S, Gerckens U, Wenaweser P, Brecker S, Tamburino C, Linke A
The Incidence and Predictors of Early- and Mid-Term Clinically Relevant Neurological Events After Transcatheter Aortic Valve Replacement in Real-World Patients.
J Am Coll Cardiol 2015; 66(3): 209-217
ISSN 0735-1097
 
Woitek F, Zentilin L, Hoffman NE, Powers JC, Ottiger I, Parikh S, Kulczycki AM, Hurst M, Ring N, Wang T, Shaikh F, Gross P, Singh H, Kolpakov MA, Linke A, Houser SR, Rizzo V, Sabri A, Madesh M, Giacca M, Recchia FA
Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy.
J Am Coll Cardiol 2015; 66(2): 139-153
ISSN 0735-1097
 
Bowen TS, Rolim NP, Fischer T, Baekkerud FH, Medeiros A, Werner S, Bronstad E, Rognmo O, Mangner N, Linke A, Schuler G, Silva GJ, Wisloff U, Adams V
Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle.
Eur J Heart Fail 2015; 17(3): 263-272
ISSN 1388-9842
 
Haussig S, Linke A
Patient selection for TAVI 2015 - TAVI in low-risk patients: fact or fiction?
EuroIntervention 2015; 11(Suppl): 86-91
ISSN 1774-024X
 
Schlotter F, Haussig S, Schuler G, Linke A
Valve-in-valve Medtronic CoreValve implantation into a degenerated transapical Ventor Embracer aortic valve bioprosthesis.
Clin Res Cardiol 2015; 104(10): 908-910
ISSN 1861-0684
 
Lurz P, Serpytis R, Blazek S, Seeburger J, Mangner N, Noack T, Ender J, Mohr FW, Linke A, Schuler G, Gutberlet M, Thiele H
Assessment of acute changes in ventricular volumes, function, and strain after interventional edge-to-edge repair of mitral regurgitation using cardiac magnetic resonance imaging.
Eur Heart J Cardiovasc Imaging 2015; 16(12): 1399-1404
ISSN 2047-2404
 
Mangner N, Weikert B, Bowen TS, Sandri M, Höllriegel R, Erbs S, Hambrecht R, Schuler G, Linke A, Gielen S, Adams V
Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm.
J Cachexia Sarcopenia Muscle 2015; 6(4): 381-390
ISSN 2190-5991
 
Matsuo Y, Gleitsmann K, Mangner N, Werner S, Fischer T, Bowen TS, Kricke A, Matsumoto Y, Kurabayashi M, Schuler G, Linke A, Adams V
Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines.
J Cachexia Sarcopenia Muscle 2015; 6(1): 62-72
ISSN 2190-5991
 
Adams V, Alves M, Fischer T, Rolim N, Werner S, Schutt N, Bowen TS, Linke A, Schuler G, Wisloff U
High-intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction.
J Appl Physiol (1985) 2015; 119(6): 745-752
ISSN 8750-7587
 
Bowen TS, Mangner N, Werner S, Glaser S, Kullnick Y, Schrepper A, Doenst T, Oberbach A, Linke A, Steil L, Schuler G, Adams V
Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation.
J Appl Physiol (1985) 2015; 118(1): 11-19
ISSN 8750-7587
 
Haussig S, Linke A. TAVR Indications SHOULD be expanded to lower risk and younger patients. Circulation, in press. (IF: 14.948)
 
Woitek F, Linke A. Interventionelle Therapie von Aortenklappenvitien: Standards und Innovationen, CardioVasc, in press (IF: n.d.).
 
Mangner N, Schuler G, Linke A, Remaining pitfalls and limitations of TAVI in 2014. Eurointervention, in press (IF: 3.758)
 
Haussig S, Schuler G, Linke A. Treatment of a Failing St. Jude Medical Trifecta by Medtronic CoreValve Evolut Valve-in-Valve Implantation. JACC Cardiovasc Interv. 2014 Jul;7(7):e81-2. (IF: 7.440)
 
Linke A, Wenaweser P, Gerckens U, Tamburino C, Bosmans J, Bleiziffer S, Blackman D, Schäfer U, Müller R, Sievert H, Søndergaard L, Klugmann S, Hoffmann R, Tchétché D, Colombo A, Legrand VM, Bedogni F, Leprince P, Schuler G, Mazzitelli D, Eftychiou C, Frerker C, Boekstegers P, Windecker S, Mohr FW, Woitek F, Lange R, Bauernschmitt R, Brecker S; For the ADVANCE study Investigators. Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study. Eur Heart J. 2014 Mar 28. [Epub ahead of print] (IF: 14.723)
 
Haussig S, Schuler G, Linke A. Worldwide TAVI registries: what have we learned? Clin Res Cardiol. 2014 Aug;103(8):603-12. doi: 10.1007/s00392-014-0698-y. (IF: 4.167)
 
Schuler G, Schroeder R, Linke A. Heart leaflet technology valve. EuroIntervention. 2013 Sep 10;9 Suppl:S115-7. doi: 10.4244/EIJV9SSA24 (IF: 3.758)
 
Mangner N, Schuler G, Linke A. Echocardiography in transcatheter aortic valve implantation. Minerva Cardioangiol. 2013 Aug;61(4):393-405. (IF: 0.43)
 
Adams V, Heiker JT, Höllriegel R, Beck EB, Woitek FJ, Erbs S, Blüher M, Stumvoll M, Beck-Sickinger AG, Schuler G, Linke A. Adiponectin promotes the migration of circulating angiogenic cells through p38-mediated induction of the CXCR4 receptor. Int J Cardiol. 2013 Sep 1;167(5):2039-46. (IF: 6.175)
 
Linke A, Woitek F, Merx MW, Schiefer C, Möbius-Winkler S, Holzhey D, Rastan A, Ender J, Walther T, Kelm M, Mohr FW, Schuler G. Valve-in-valve implantation of Medtronic CoreValve prosthesis in patients with failing bioprosthetic aortic valves. Circ Cardiovasc Interv. 2012 Oct;5(5):689-97. doi: 10.1161/CIRCINTERVENTIONS.112.972331. (IF: 6.543)
 
Mangner N, Gutberlet M, Klingel K, Kandolf R, Schuler G, Linke A. A rare cause of cardiac decompensation in a patient with left ventricular hypertrophy. Clin Res Cardiol. 2012 Nov;101(11):943-5. doi: 10.1007/s00392-012-0478-5. (IF: 3.667)
 
Woitek FJ, Linke A. [Aortic valve stenosis: Matching the approach to the patient]. Dtsch Med Wochenschr. 2012 Mar;137(13):648-51. doi: 10.1055/s-0031-1298990 (IF: 0.653)
 
Beck EB, Erbs S, Möbius-Winkler S, Adams V, Woitek FJ, Walther T, Hambrecht R, Mohr FW, Stumvoll M, Blüher M, Schuler G, Linke A. Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease. Eur J Prev Cardiol. 2012 Jun;19(3):412-8. doi: 10.1177/1741826711403068. (IF: 3.903)
 
Linke A. [Percutaneous aortic valve implantation: transapical versus transfemoral access - For transfemoral]. Dtsch Med Wochenschr. 2010 Apr;135(13):616. doi: 10.1055/s-0030-1251901. (IF: 0.500)
 
Matsumoto Y, Adams V, Jacob S, Mangner N, Schuler G, Linke A. Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice. Circulation. 2010 Feb 16;121(6):759-67. doi: 10.1161/CIRCULATIONAHA.109.892224. (IF: 14.432)
 
Linke A, Walther T, Schuler G. The utility of trans-catheter aortic valve replacement after commercialization: does the European experience provide a glimpse into the future use of this technology in the United States? Catheter Cardiovasc Interv. 2010 Mar 1;75(4):511-8. doi: 10.1002/ccd.22346. (IF: 2.398)
 
Linke A, Sonnabend M, Fasshauer M, Höllriegel R, Schuler G, Niebauer J, Stumvoll M, Blüher M. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance. Atherosclerosis. 2009 Jul;205(1):207-13. (IF: 4.522)
 
Linke A, Höllriegel R, Walther T, Schierle K, Wittekind C, Ender J, Mohr FW, Schuler G. 117. Ingrowths of a percutaneously implanted aortic valve prosthesis (corevalve) in a patient with severe aortic stenosis. Circ Cardiovasc Interv. 2008 Oct;1(2):155-8. doi: 10.1161/CIRCINTERVENTIONS.108.796094. (IF: n.d.)
 
Linke A, Erbs S, Hambrecht R. Effects of exercise training upon endothelial function in patients with cardiovascular disease. Front Biosci. 2008 Jan 1;13:424-32 (IF: 3.308)
 
Linke A, Mobius-Winkler S, Hambrecht R: Exercise Training in the treatment of coronary artery disease and obesity. Herz 2006 May;31(3):224-233. (IF: 0.952)
 
Linke A, Erbs S, Hambrecht R: Exercise and the coronary circulation - alterations and adaptations in coronary artery disease. Prog Cardiovasc Dis. 2006 Jan-Feb;48(4):270-84. (IF: 2.844)
 
Linke A, Erbs S, Hambrecht R: Flow-mediated vasodilatation partially reflects nitric oxide mediated endothelial function. J Appl Physiol. 2005 Oct;99(4):1622. (IF: 3.037)
 
Linke A, Muller P, Nurzynska D, Casarsa C, Torella D, Nascimbene A, Castaldo C, Cascapera S, Bohm M, Quaini F, Urbanek K, Leri A, Hintze TH, Kajstura J, Anversa P: Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A 2005 June 21;102(25):8966-71. (IF: 10.231)
 
Linke A, Adams V, Schulze PC, Erbs S, Gielen S, Fiehn E, Mobius-Winkler S, Schubert A, Schuler G, Hambrecht R: Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation. 2005 Apr 12;111(14):1763-70. (IF: 11.632)
 
Linke A, Li W, Huang H, Wang Z, Hintze TH: Role of cardiac eNOS expression during pregnancy in the coupling of myocardial oxygen consumption to cardiac work. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1208-14. (IF: 3.369)
 
Linke A, Schoene N, Gielen S, Erbs S, Walther C, Schuler G, Hambrecht R: Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower limb exercise training. J Am Coll Cardiol 2001;37 (2):392-7. (IF: 6.374)
 
Buchbeiträge
 
Linke A, Hambrecht R: Körperliche Aktivität bei koronarer Herzkrankheit. In "Halle: Sporttherapie internistischer Erkrankungen", Schattauer, Stuttgart - New York, 2008:59-68.
 
Linke A, Hambrecht R: Körperliche Aktivität bei chronischer Herzinsuffizienz. In "Halle: Sporttherapie internistischer Erkrankungen", Schattauer, Stuttgart - New York, 2008:83-90.
 
Linke A, Recchia F, Zhang X, Hintze TH: Acute and chronic endothelial dysfunction: implications for the development of heart failure. In Bodh I. Jugdutt (ed.): The role of nitric oxide in heart failure. Kluwer Academic Publishers, Boston/Dordrecht/London 2004:101-111.
 
KOAUTORENSCHAFTEN
 
Shin DI, Merx MW, Meyer C, Kirmanoglou K, Hellhammer K, Ohlig J, Katsani D, Zeus T, Westenfeld R, Eickholt C, Linke A, Kelm M
Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation.
Acta Cardiol 2015; 70(5): 574-580
ISSN 0001-5385
 
Schaefer U, Zahn R, Abdel-Wahab M, Gerckens U, Linke A, Schneider S, Eggebrecht H, Sievert H, Figulla HR, Senges J, Kuck KH
Comparison of outcomes of patients with left ventricular ejection fractions ?30% versus ?30% having transcatheter aortic valve implantation (from the German Transcatheter Aortic Valve Interventions Registry).
Am J Cardiol 2015; 115(5): 656-663
ISSN 0002-9149
 
Dangas GD, Lefevre T, Kupatt C, Tchetche D, Schafer U, Dumonteil N, Webb JG, Colombo A, Windecker S, Ten Berg JM, Hildick-Smith D, Mehran R, Boekstegers P, Linke A, Tron C, Van Belle E, Asgar AW, Fach
Bivalirudin Versus Heparin Anticoagulation in Transcatheter Aortic Valve Replacement: The Randomized BRAVO-3 Trial.
J Am Coll Cardiol 2015; 66(25): 2860-2868
ISSN 0735-1097
 
Kiefer P, Seeburger J, Noack T, Schroter T, Linke A, Schuler G, Haensig M, Vollroth M, Mohr FW, Holzhey DM
The role of the heart team in complicated transcatheter aortic valve implantation: a 7-year single-centre experience.
Eur J Cardiothorac Surg 2015; 47(6): 1090-1096
ISSN 1010-7940
 
Mukherjee C, Holzhey D, Mende M, Linke A, Kaisers UX, Ender J
Initial Experience With a Percutaneous Approach to Redo Mitral Valve Surgery: Management and Procedural Success.
J Cardiothorac Vasc Anesth 2015; 29(4): 889-897
ISSN 1053-0770
 
Zhang YJ, Iqbal J, Windecker S, Linke A, Antoni D, Sohn HY, Corti R, van Es GA, Copt S, Eerdmans P, Saitta R, Morice MC, Di Mario C, Juni P, Wijns W, Buszman P, Serruys PW
Biolimus-eluting stent with biodegradable polymer improves clinical outcomes in patients with acute myocardial infarction.
Heart 2015; 101(4): 271-278
ISSN 1355-6037
 
Poss J, Fürnau G, Denks D, Desch S, Eitel I, de Waha S, Linke A, Schuler G, Adams V, Bohm M, Thiele H
Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-a biomarker substudy of the IABP-SHOCK II-Trial.
Eur J Heart Fail 2015; 17(11): 1152-1160
ISSN 1388-9842
 
von Aspern K, Foldyna B, Etz CD, Hoyer A, Girrbach F, Holzhey D, Lucke C, Grothoff M, Linke A, Mohr FW, Gutberlet M, Lehmkuhl L
Effective diameter of the aortic annulus prior to transcatheter aortic valve implantation: influence of area-based versus perimeter-based calculation.
Int J Cardiovasc Imaging 2015; 31(1): 163-169
ISSN 1569-5794
 
Mobius-Winkler S, Majunke N, Sandri M, Mangner N, Linke A, Stone GW, Dähnert I, Schuler G, Sick PB
Percutaneous left atrial appendage closure: Technical aspects and prevention of periprocedural complications with the watchman device.
World J Cardiol 2015; 7(2): 65-75
ISSN 1949-8462
 
Abdel-Wahab M, Zahn R, Gerckens U, Linke A, Sievert H, Schäfer U, Kahlert P, Hambrecht R, Sack S, Hoffmann E, Senges J, Schneider S, Richardt G; German TAVI Registry Investigators. Predictors of 1-year mortality in patients with aortic regurgitation after transcatheter aortic valve implantation: an analysis from the multicentre German TAVI registry. Heart. 2014 Aug 15;100(16):1250-6. doi: 10.1136/heartjnl-2013-305385. (IF: 6.023)
 
Balzer JC, Boering YC, Mollus S, Schmidt M, Hellhammer K, Kroepil P, Westenfeld R, Zeus T, Antoch G, Linke A, Steinseifer U, Merx MW, Kelm M. Left ventricular contrast injection with rotational C-arm CT improves accuracy of aortic annulus measurement during cardiac catheterisation. EuroIntervention. 2014 Jul 20;10(3):347-54. doi: 10.4244/EIJV10I3A60. (IF: 3.758)
 
Haensig M, Holzhey DM, Borger MA, Linke A, Seeburger J, Lehmann S, Schuler G, Mohr FW. Improved mitral valve performance after transapical aortic valve implantation. Ann Thorac Surg. 2014 Apr;97(4):1247-53; discussion 1253-4. doi: 10.1016/j.athoracsur.2013.11.025. Epub 2014 Feb 8. (IF: 3.631)
 
Lehmkuhl L, Foldyna B, Haensig M, von Aspern K, Lücke C, Andres C, Grothoff M, Riese F, Nitzsche S, Holzhey D, Linke A, Mohr FW, Gutberlet M. Role of preprocedural computed tomography in transcatheter aortic valve implantation. Rofo. 2013 Oct;185(10):941-9. Review. (IF: 1.961)
 
Sündermann SH, Grünenfelder J, Corti R, Rastan AJ, Linke A, Lange R, Falk V, Bleiziffer S. Outcome of patients treated with engager transapical aortic valve implantation: one-year results of the feasibility study. Innovations (Phila). 2013 Sep-Oct;8(5):332-6. doi: 10.1097/IMI.0000000000000018. (IF: 0.600)
 
Bauer T, Linke A, Sievert H, Kahlert P, Hambrecht R, Nickenig G, Hauptmann KE, Sack S, Gerckens U, Schneider S, Zeymer U, Zahn R. Comparison of the effectiveness of transcatheter aortic valve implantation in patients with stenotic bicuspid versus tricuspid aortic valves (from the German TAVI Registry). Am J Cardiol. 2014 Feb 1;113(3):518-21. doi: 10.1016/j.amjcard.2013.10.023. (3.425)
 
Gutberlet M, Foldyna B, Grothoff M, Lücke C, Riese F, Nitzsche S, Haensig M, von Aspern K, Holzhey D, Thiele H, Schuler G, Linke A, Mohr FW, Lehmkuhl L.[Imaging prior to transcatheter aortic valve implantation]. Radiologe. 2013 Oct;53(10):886-95. doi: 10.1007/s00117-012-2472-3. German. (IF: 0.414)
 
Adams V, Besler C, Fischer T, Riwanto M, Noack F, Höllriegel R, Oberbach A, Jehmlich N, Völker U, Winzer EB, Lenk K, Hambrecht R, Schuler G, Linke A, Landmesser U, Erbs S. Exercise training in patients with chronic heart failure promotes restoration of high-density lipoprotein functional properties. Circ Res. 2013 Dec 6;113(12):1345-55. doi: 10.1161/CIRCRESAHA.113.301684. (IF: 11.089)
 
Holzhey D, Linke A, Treede H, Baldus S, Bleiziffer S, Wagner A, Börgermann J, Scholtz W, Vanoverschelde JL, Falk V. Intermediate follow-up results from the multicenter engager European pivotal trial. Ann Thorac Surg. 2013 Dec;96(6):2095-100. doi: 10.1016/j.athoracsur.2013.06.089. (IF: 3.631)
 
Serruys PW, Farooq V, Kalesan B, de Vries T, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Wijns W, Morice MC, Di Mario C, Corti R, Antoni D, Sohn HY, Eerdmans P, Rademaker-Havinga T, van Es GA, Meier B, Jüni P, Windecker S. Improved safety and reduction in stent thrombosis associated with biodegradable polymer-based biolimus-eluting stents versus durable polymer-based sirolimus-eluting stents in patients with coronary artery disease: final 5-year report of the LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) randomized, noninferiority trial. JACC Cardiovasc Interv. 2013 Aug;6(8):777-89. doi: 10.1016/j.jcin.2013.04.011. (IF: 7.440)
 
Stiermaier T, Heinz A, Schloma D, Kleinertz K, Dänschel W, Erbs S, Linke A, Boudriot E, Lauer B, Schuler G, Thiele H, Desch S. Five-year clinical follow-up of a randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus (LIPSIA Yukon trial). Catheter Cardiovasc Interv. 2014 Feb 15;83(3):418-24. doi: 10.1002/ccd.25131. (IF: 2.396)
 
Matsuo Y, Oberbach A, Till H, Inge TH, Wabitsch M, Moss A, Jehmlich N, Völker U, Müller U, Siegfried W, Kanesawa N, Kurabayashi M, Schuler G, Linke A, Adams V. Impaired HDL function in obese adolescents: impact of lifestyle intervention and bariatric surgery. Obesity (Silver Spring). 2013 Dec;21(12):E687-95. doi: 10.1002/oby.20538. (IF: 4.389)
 
Haensig M, Kiefer P, Linke A, Mukherjee C, Mohr FW, Holzhey DM. Transapical aortic valve-in-valve implantation using a 'partially inflated valvuloplasty balloon' for valve recovery out of the left ventricle. Eur Heart J. 2013 Jul;34(25):1884. doi: 10.1093/eurheartj/eht175 (IF: 14.723)
 
Zahn R, Gerckens U, Linke A, Sievert H, Kahlert P, Hambrecht R, Sack S, Abdel-Wahab M, Hoffmann E, Schiele R, Schneider S, Senges J; German Transcatheter Aortic Valve Interventions-Registry Investigators. Predictors of one-year mortality after transcatheter aortic valve implantation for severe symptomatic aortic stenosis. Am J Cardiol. 2013 Jul 15;112(2):272-9. doi: 10.1016/j.amjcard.2013.03.024. (IF: 3.425)
 
Ledwoch J, Franke J, Gerckens U, Kuck KH, Linke A, Nickenig G, Krülls-Münch J, Vöhringer M, Hambrecht R, Erbel R, Richardt G, Horack M, Zahn R, Senges J, Sievert H; German Transcatheter Aortic Valve Interventions Registry Investigators. Incidence and predictors of permanent pacemaker implantation following transcatheter aortic valve implantation: analysis from the German transcatheter aortic valve interventions registry. Catheter Cardiovasc Interv. 2013 Oct 1;82(4):E569-77. doi: 10.1002/ccd.24915 (IF: 2.396)
 
Roy DA, Schaefer U, Guetta V, Hildick-Smith D, Möllmann H, Dumonteil N, Modine T, Bosmans J, Petronio AS, Moat N, Linke A, Moris C, Champagnac D, Parma R, Ochala A, Medvedofsky D, Patterson T, Woitek F, Jahangiri M, Laborde JC, Brecker SJ. Transcatheter aortic valve implantation for pure severe native aortic valve regurgitation. J Am Coll Cardiol. 2013 Apr 16;61(15):1577-84. doi: 10.1016/j.jacc.2013.01.018. (IF: 15.343)
 
Haensig M, Holzhey DM, Lehmkuhl L, Lehmann S, Linke A, Schuler G, Girrbach F, Moscoso-Luduena M, Borger MA, Rastan AJ, Mohr FW. Experience with anatomically orientated devices for transapical aortic valve implantation. Minerva Cardioangiol. 2013 Feb;61(1):33-43. Review. (IF: 0.430)
 
Höllriegel R, Linke A, Hochadel M, Schuler G, Kerber S, Hambrecht R, Grube E, Hauptmann KE, Zahn R, Zeymer U, Senges J. Impact of coronary artery disease on in-hospital mortality in patients with aortic valve disease. Results from the German ALKK registry. Herz. 2013 Jun;38(4):387-90. doi: 10.1007/s00059-012-3712-z. (IF: 0.780)
 
Mangner N, Linke A, Oberbach A, Kullnick Y, Gielen S, Sandri M, Hoellriegel R, Matsumoto Y, Schuler G, Adams V. Exercise training prevents TNF-? induced loss of force in the diaphragm of mice. PLoS One. 2013;8(1):e52274. doi: 10.1371/journal.pone.0052274. (IF: 3.534)
 
Zahn R, Schiele R, Gerckens U, Linke A, Sievert H, Kahlert P, Hambrecht R, Sack S, Abdel-Wahab M, Hoffmann E, Senges J; German Transcatheter Aortic Valve Interventions Registry Investigators. Transcatheter aortic valve implantation in patients with "porcelain" aorta (from a Multicenter Real World Registry). Am J Cardiol. 2013 Feb 15;111(4):602-8. doi: 10.1016/j.amjcard.2012.11.004 (IF: 3.425)
 
Kackstein K, Teren A, Matsumoto Y, Mangner N, Möbius-Winkler S, Linke A, Schuler G, Punkt K, Adams V. Impact of angiotensin II on skeletal muscle metabolism and function in mice: contribution of IGF-1, Sirtuin-1 and PGC-1?. Acta Histochem. 2013 May;115(4):363-70. doi: 10.1016/j.acthis.2012.09.009. (IF: 1.760)
 
Buellesfeld L, Gerckens U, Erbel R, Zahn R, Linke A, Sievert H, Figulla HR, Kuck KH, Hauptmann KE, Hambrecht R, Richardt G, Naber C, Voehringer M, Mudra H, Senges J, Grube E; German TAVI Registry Investigators. Age-stratified baseline and outcome characteristics of patients undergoing transcatheter aortic valve implantation: results from the German multicenter registry. J Invasive Cardiol. 2012 Oct;24(10):531-6. PubMed PMID: 23043037. (IF: 1.569)
 
Kempfert J, Rastan A, Holzhey D, Linke A, Schuler G, Mohr FW, Walther T. The learning curve associated with transapical aortic valve implantation. Ann Cardiothorac Surg. 2012 Jul;1(2):165-71. doi:10.3978/j.issn.2225-319X.2012.07.07. (IF: 3.454)
 
Holzhey DM, Hänsig M, Walther T, Seeburger J, Misfeld M, Linke A, Borger MA, Mohr FW. Transapical aortic valve implantation - The Leipzig experience. Ann Cardiothorac Surg. 2012 Jul;1(2):129-37. doi:10.3978/j.issn.2225-319X.2012.06.09. (IF: 3.454)
 
Uhlemann M, Adams V, Lenk K, Linke A, Erbs S, Adam J, Thiele H, Hilberg T, Gutberlet M, Grunze M, Schuler GC, Möbius-Winkler S. Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial. Trials. 2012 Sep 14;13:167. doi: 10.1186/1745-6215-13-167. (IF: 2.206)
 
Sinning JM, Horack M, Grube E, Gerckens U, Erbel R, Eggebrecht H, Zahn R, Linke A, Sievert H, Figulla HR, Kuck KH, Hauptmann KE, Hoffmann E, Hambrecht R, Richardt G, Sack S, Senges J, Nickenig G, Werner N. The impact of peripheral arterial disease on early outcome after transcatheter aortic valve implantation: results from the German Transcatheter Aortic Valve Interventions Registry. Am Heart J. 2012 Jul;164(1):102-10.e1. doi: 10.1016/j.ahj.2012.04.016. (IF: 4.497)
 
Sündermann SH, Grünenfelder J, Corti R, Rastan AJ, Linke A, Lange R, Falk V, Bleiziffer S. Feasibility of the Engagerâ„¢ aortic transcatheter valve system using a flexible over-the-wire design. Eur J Cardiothorac Surg. 2012 Oct;42(4):e48-52. doi: 10.1093/ejcts/ezs389. (IF: 2.674)
 
Schroeter T, Linke A, Haensig M, Merk DR, Borger MA, Mohr FW, Schuler G. Predictors of permanent pacemaker implantation after Medtronic CoreValve bioprosthesis implantation. Europace. 2012 Dec;14(12):1759-63. doi: 10.1093/europace/eus191. (2.765)
 
Lehmkuhl LH, von Aspern K, Foldyna B, Grothoff M, Nitzsche S, Kempfert J, Rastan A, Linke A, Mohr FW, Noettling A, Walther T, Gutberlet M. Comparison of aortic root measurements in patients undergoing transapical aortic valve implantation (TA-AVI) using three-dimensional rotational angiography (3D-RA) and multislice computed tomography (MSCT): differences and variability. Int J Cardiovasc Imaging. 2013 Feb;29(2):417-24. doi: 10.1007/s10554-012-0081-x. (IF: 2.322)
 
Lauten A, Zahn R, Horack M, Sievert H, Linke A, Ferrari M, Harnath A, Grube E, Gerckens U, Kuck KH, Sack S, Senges J, Figulla HR; German Transcatheter Aortic Valve Interventions Registry Investigators. Transcatheter aortic valve implantation in patients with low-flow, low-gradient aortic stenosis. JACC Cardiovasc Interv. 2012 May;5(5):552-9. doi: 10.1016/j.jcin.2012.04.001. (IF: 6.552)
 
Schlotter F, Matsumoto Y, Mangner N, Schuler G, Linke A, Adams V. Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice. PLoS One. 2012;7(5):e37298. doi: 10.1371/journal.pone.0037298. (IF: 3.730)
 
Arsalan M, Woitek F, Adams V, Linke A, Barten MJ, Dhein S, Walther T, Mohr FW, Garbade J. Distribution of cardiac stem cells in the human heart. ISRN Cardiol. 2012;2012:483407. doi: 10.5402/2012/483407. (IF: n.d.)
 
Höllriegel R, Beck EB, Linke A, Adams V, Möbius-Winkler S, Mangner N, Sandri M, Gielen S, Gutberlet M, Hambrecht R, Schuler G, Erbs S. Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size. Int J Cardiol. 2013 Aug 10;167(3):975-80. doi: 10.1016/j.ijcard.2012.03.083. (IF: 6.175)
 
Sandri M, Kozarez I, Adams V, Mangner N, Höllriegel R, Erbs S, Linke A, Möbius-Winkler S, Thiery J, Kratzsch J, Teupser D, Mende M, Hambrecht R, Schuler G, Gielen S. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J. 2012 Jul;33(14):1758-68. doi: 10.1093/eurheartj/ehr469. (IF: 14.097)
 
Uhlemann M, Möbius-Winkler S, Mende M, Eitel I, Fuernau G, Sandri M, Adams V, Thiele H, Linke A, Schuler G, Gielen S. The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications. JACC Cardiovasc Interv. 2012 Jan;5(1):36-43. (IF: 6.551)
 
Stefanini GG, Kalesan B, Serruys PW, Heg D, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Wijns W, Morice MC, Di Mario C, Corti R, Antoni D, Sohn HY, Eerdmans P, van Es GA, Meier B, Windecker S, Jüni P. Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymersirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial. Lancet. 2011 Dec3;378(9807):1940-8. doi: 10.1016/S0140-6736(11)61672-3. (IF: 38.278)
 
Wykrzykowska J, Serruys P, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, Di Mario C, Van Geuns RJ, Van Es GA, Juni P, Windecker S. The three year follow-up of the randomised "all-comers" trial of a biodegradable polymer biolimus-eluting stent versus permanent polymer sirolimus-eluting stent (LEADERS). EuroIntervention. 2011 Nov;7(7):789-95. doi:10.4244/EIJV7I7A125. PubMed PMID: 22027687. (IF: 3.285)
 
Kempfert J, Rastan A, Holzhey D, Linke A, Schuler G, van Linden A, Blumenstein J, Mohr FW, Walther T. Transapical aortic valve implantation: analysis of risk factors and learning experience in 299 patients. Circulation. 2011 Sep 13;124(11 Suppl):S124-9. doi: 10.1161/CIRCULATIONAHA.110.013425. (14.739)
 
Wykrzykowska JJ, Garg S, Onuma Y, de Vries T, Morel MA, van Es GA, Buszman P, Linke A, Ischinger T, Klauss V, Corti R, Eberli F, Wijns W, Morice MC, Di Mario C, van Geuns RJ, Juni P, Windecker S, Serruys PW. Implantation of the biodegradable polymer biolimus-eluting stent in patients with high SYNTAX score is associated with decreased cardiac mortality compared to a permanent polymer sirolimus-eluting stent: two year follow-up results from the "all-comers" LEADERS trial. EuroIntervention. 2011 Sep;7(5):605-13. doi: 10.4244/EIJV7I5A97. (IF: 3.285)
 
Klauss V, Serruys PW, Pilgrim T, Buszman P, Linke A, Ischinger T, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, van Geuns RJ, van Es GA, Kalesan B, Wenaweser P, Jüni P, Windecker S. 2-year clinical follow-up from the randomized comparison of biolimus-eluting stents with biodegradable polymer and sirolimus-eluting stents with durable polymer in routine clinical practice. JACC Cardiovasc Interv. 2011 Aug;4(8):887-95. doi: 10.1016/j.jcin.2011.03.017. (IF: 6.800)
 
Walther T, Kempfert J, Rastan A, Borger MA, Linke A, Ender J, Schuler G, Mohr FW. Transapical aortic valve implantation at 3 years. J Thorac Cardiovasc Surg. 2012 Feb;143(2):326-31. doi: 10.1016/j.jtcvs.2010.10.063. (IF: 3.536)
 
Stefanini GG, Serruys PW, Silber S, Khattab AA, van Geuns RJ, Richardt G, Buszman PE, Kelbæk H, van Boven AJ, Hofma SH, Linke A, Klauss V, Wijns W, Macaya C, Garot P, Di Mario C, Manoharan G, Kornowski R, Ischinger T, Bartorelli AL, Gobbens P, Windecker S. The impact of patient and lesion complexity on clinical and angiographic outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial (a randomized comparison of a zotarolimus-eluting stent with an everolimus-eluting stent for percutaneous coronary intervention). J Am Coll Cardiol. 2011 May 31;57(22):2221-32. doi: 10.1016/j.jacc.2011.01.036. (IF: 14.156)
 
Kempfert J, Rastan AJ, Schuler G, Linke A, Holzhey D, van Linden A, Mohr FW, Walther T. A second prosthesis as a procedural rescue option in trans-apical aortic valve implantation. Eur J Cardiothorac Surg. 2011 Jul;40(1):56-60. doi: 10.1016/j.ejcts.2011.03.020. (IF: 2.550)
 
Desch S, Schloma D, Möbius-Winkler S, Erbs S, Gielen S, Linke A, Yu J, Lauer B, Kleinertz K, Dänschel W, Schuler G, Thiele H. Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trial. JACC Cardiovasc Interv. 2011 Apr;4(4):452-9. doi: 10.1016/j.jcin.2010.11.016. (IF: 6.800)
 
Garg S, Serruys PW, Silber S, Wykrzykowska J, van Geuns RJ, Richardt G, Buszman PE, Kelbæk H, van Boven AJ, Hofma SH, Linke A, Klauss V, Wijns W, Macaya C, Garot P, DiMario C, Manoharan G, Kornowski R, Ischinger T, Bartorelli A, Van Remortel E, Ronden J, Windecker S. The prognostic utility of the SYNTAX score on 1-year outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial. JACC Cardiovasc Interv. 2011 Apr;4(4):432-41. doi: 10.1016/j.jcin.2011.01.008. (IF: 3.285)
 
Silber S, Windecker S, Vranckx P, Serruys PW; RESOLUTE All Comers investigators. Unrestricted randomised use of two new generation drug-eluting coronary stents: 2-year patient-related versus stent-related outcomes from the RESOLUTE All Comers trial. Lancet. 2011 Apr 9;377(9773):1241-7. doi: 10.1016/S0140-6736(11)60395-4. (IF: 38.278)
 
Lenk K, Erbs S, Höllriegel R, Beck E, Linke A, Gielen S, Winkler SM, Sandri M, Hambrecht R, Schuler G, Adams V. Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. Eur J Prev Cardiol. 2012 Jun;19(3):404-11. doi: 10.1177/1741826711402735. (IF: 3.903)
 
Støylen A, Conraads V, Halle M, Linke A, Prescott E, Ellingsen Ø. Controlled study of myocardial recovery after interval training in heart failure: SMARTEX-HF-rationale and design. Eur J Prev Cardiol. 2012 Aug;19(4):813-21. (IF: 3.903)
 
Garg S, Wykrzykowska J, Serruys PW, de Vries T, Buszman P, Trznadel S, Linke A, Lenk K, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, Tyczynski P, van Geuns RJ, Eerdmans P, van Es GA, Meier B, Jüni P, Windecker S. The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer. EuroIntervention. 2011 Mar;6(8):928-35. doi: 10.4244/EIJV6I8A162. (IF: 3.285)
 
Wykrzykowska JJ, Garg S, Onuma Y, de Vries T, Goedhart D, Morel MA, van Es GA, Buszman P, Linke A, Ischinger T, Klauss V, Corti R, Eberli F, Wijns W, Morice MC, di Mario C, van Geuns RJ, Juni P, Windecker S, Serruys PW. Value of age, creatinine, and ejection fraction (ACEF score) in assessing risk in patients undergoing percutaneous coronary interventions in the 'All-Comers' LEADERS trial. Circ Cardiovasc Interv. 2011 Feb 1;4(1):47-56. doi: 10.1161/CIRCINTERVENTIONS.110.958389. (IF: 6.058)
 
Falk V, Walther T, Schwammenthal E, Strauch J, Aicher D, Wahlers T, Schäfers J, Linke A, Mohr FW. Transapical aortic valve implantation with a self-expanding anatomically oriented valve. Eur Heart J. 2011 Apr;32(7):878-87. doi: 10.1093/eurheartj/ehq445. (IF: 10.479)
 
Müller UM, Eitel I, Eckrich K, Erbs S, Linke A, Möbius-Winkler S, Mende M, Schuler GC, Thiele H. Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centre. Clin Res Cardiol. 2011 Apr;100(4):297-309. doi: 10.1007/s00392-010-0242-7. (IF: 2.961)
 
Kempfert J, Van Linden A, Linke A, Schuler G, Rastan A, Lehmann S, Lehmkuhl L, Mohr FW, Walther T. Transapical aortic valve implantation: therapy of choice for patients with aortic stenosis and porcelain aorta? Ann Thorac Surg. 2010 Nov;90(5):1457-61. doi: 10.1016/j.athoracsur.2010.06.080. (IF: 3.792)
 
Zahn R, Gerckens U, Grube E, Linke A, Sievert H, Eggebrecht H, Hambrecht R, Sack S, Hauptmann KE, Richardt G, Figulla HR, Senges J; German Transcatheter Aortic Valve Interventions-Registry Investigators. Transcatheter aortic valve implantation: first results from a multi-centre real-world registry. Eur Heart J. 2011 Jan;32(2):198-204. doi: 10.1093/eurheartj/ehq339. (IF: 10.478)
 
Lauten A, Linke A, Figulla HR, Hekmat K, Ragoschke-Schumm A, Krizanic F, Jung C, Goebel B, Ferrari M. Transfemoral aortic valve implantation for severe aortic regurgitation after david procedure. J Am Coll Cardiol. 2010 Sep 28;56(14):1158. doi: 10.1016/j.jacc.2010.02.074. (IF: 14.293)
 
Wykrzykowska JJ, Garg S, Girasis C, de Vries T, Morel MA, van Es GA, Buszman P, Linke A, Ischinger T, Klauss V, Corti R, Eberli F, Wijns W, Morice MC, di Mario C, van Geuns RJ, Juni P, Windecker S, Serruys PW. Value of the SYNTAX score for risk assessment in the all-comers population of the randomized multicenter LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) trial. J Am Coll Cardiol. 2010 Jul 20;56(4):272-7. doi: 10.1016/j.jacc.2010.03.044. (IF: 14.293)
 
Sandri M, Beck EB, Adams V, Gielen S, Lenk K, Höllriegel R, Mangner N, Linke A, Erbs S, Möbius-Winkler S, Scheinert D, Hambrecht R, Schuler G. Maximal exercise, limb ischemia, and endothelial progenitor cells. Eur J Cardiovasc Prev Rehabil. 2011 Feb;18(1):55-64. doi: 10.1097/HJR.0b013e32833ba654. (IF: 2.634)
 
Garg S, Sarno G, Serruys PW, de Vries T, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, Di Mario C, van Geuns RJ, Eerdmans P, van Es GA, Meier B, Jüni P, Windecker S. The twelve-month outcomes of a biolimus eluting stent with a biodegradable polymer compared with a sirolimus eluting stent with a durable polymer. EuroIntervention. 2010 Jun;6(2):233-9. doi:10.4244/. (IF: n.d.)
 
Serruys PW, Silber S, Garg S, van Geuns RJ, Richardt G, Buszman PE, Kelbaek H, van Boven AJ, Hofma SH, Linke A, Klauss V, Wijns W, Macaya C, Garot P, DiMario C, Manoharan G, Kornowski R, Ischinger T, Bartorelli A, Ronden J, Bressers M, Gobbens P, Negoita M, van Leeuwen F, Windecker S. Comparison of zotarolimus-eluting and everolimus-eluting coronary stents. N Engl J Med. 2010 Jul 8;363(2):136-46. doi: 10.1056/NEJMoa1004130 (IF: 53.486)
 
Kempfert J, Van Linden A, Linke A, Borger MA, Rastan A, Mukherjee C, Ender J, Schuler G, Mohr FW, Walther T. Transapical off-pump valve-in-valve implantation in patients with degenerated aortic xenografts. Ann Thorac Surg. 2010 Jun;89(6):1934-41. doi: 10.1016/j.athoracsur.2010.02.061. (IF: 3.792)
 
Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fuernau G, Erbs S, Linke A, Diederich KW, Nowak M, Desch S, Gutberlet M, Schuler G. Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. J Am Coll Cardiol. 2010 May 18;55(20):2201-9. doi:10.1016/j.jacc.2009.08.091. (IF: 14.293)
 
Kempfert J, Lehmann S, Linke A, Rastan A, Van Linden A, Blumenstein J, Schuler G, Mohr FW, Walther T. Latest advances in transcatheter aortic valve implantation. Surg Technol Int. 2010 Apr;19:147-54. Review. (IF: n.d.)
 
Erbs S, Höllriegel R, Linke A, Beck EB, Adams V, Gielen S, Möbius-Winkler S, Sandri M, Kränkel N, Hambrecht R, Schuler G. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail. 2010 Jul;3(4):486-94. doi: 10.1161/CIRCHEARTFAILURE.109.868992. (IF: 4.313)
 
Möbius-Winkler S, Linke A, Adams V, Schuler G, Erbs S. How to improve endothelial repair mechanisms: the lifestyle approach. Expert Rev Cardiovasc Ther. 2010 Apr;8(4):573-80. doi: 10.1586/erc.10.7. Review. (IF: n.d.)
 
Erbs S, Beck EB, Linke A, Adams V, Gielen S, Kränkel N, Möbius-Winkler S, Höllriegel R, Thiele H, Hambrecht R, Schuler G. High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study. Int J Cardiol. 2011 Jan 7;146(1):56-63. doi: 10.1016/j.ijcard.2010.02.019. (IF: 7.078)
 
Walther T, Schuler G, Borger MA, Kempfert J, Seeburger J, Rückert Y, Ender J, Linke A, Scholz M, Falk V, Mohr FW. Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement. Eur Heart J. 2010 Jun;31(11):1398-403. doi: 10.1093/eurheartj/ehq060. (IF: 10.052)
 
Sarno G, Garg S, Onuma Y, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, van Geuns RJ, Eerdmans P, Garcia-Garcia HM, van Es GA, Goedhart D, de Vries T, Jüni P, Meier B, Windecker S, Serruys P. The impact of body mass index on the one year outcomes of patients treated by percutaneous coronary intervention with Biolimus- and Sirolimus-eluting stents (from the LEADERS Trial). Am J Cardiol. 2010 Feb 15;105(4):475-9. doi: 10.1016/j.amjcard.2009.09.055. (IF: 3.681)
 
Piazza N, Grube E, Gerckens U, Schuler G, Linke A, den Heijer P, Kovacs J, Spyt T, Laborde JC, Morel MA, Nuis RJ, Garcia-Garcia HM, de Jaegere P, Serruys PW. A clinical protocol for analysis of the structural integrity of the Medtronic CoreValve System frame and its application in patients with 1-year minimum follow-up. EuroIntervention. 2010 Jan;5(6):680-6. (IF: n.d.)
 
Kempfert J, Lehmann S, Linke A, Rastan A, Van Linden A, Blumenstein J, Schuler G, Mohr FW, Walther T. Transapical transcatheter off-pump aortic valve implantation. Multimed Man Cardiothorac Surg. 2010 Jan 1;2010(602):mmcts.2009.003939. doi: 10.1510/mmcts.2009.003939. (IF: n.d.)
 
Kempfert J, Falk V, Schuler G, Linke A, Merk D, Mohr FW, Walther T. Dyna-CT during minimally invasive off-pump transapical aortic valve implantation. Ann Thorac Surg. 2009 Dec;88(6):2041. doi: 10.1016/j.athoracsur.2009.01.029. (IF: 3.644)
 
Conraads VM, Vrints CJ, Rodrigus IE, Hoymans VY, Van Craenenbroeck EM, Bosmans J, Claeys MJ, Van Herck P, Linke A, Schuler G, Adams V. Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling? Basic Res Cardiol. 2010 Mar;105(2):219-26. doi: 10.1007/s00395-009-0068-5. (IF: 6.128)
 
Wykrzykowska JJ, Serruys PW, Onuma Y, de Vries T, van Es GA, Buszman P, Linke A, Ischinger T, Klauss V, Corti R, Eberli F, Wijns W, Morice MC, di Mario C, van Geuns RJ, Juni P, Windecker S. Impact of vessel size on angiographic and clinical outcomes of revascularization with biolimus-eluting stent with biodegradable polymer and sirolimus-eluting stent with durable polymer the LEADERS trial substudy. JACC Cardiovasc Interv. 2009 Sep;2(9):861-70. doi:10.1016/j.jcin.2009.05.024. (IF: n.d.)
 
Wykrzykowska JJ, Räber L, de Vries T, Bressers M, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, Regar E, Jüni P, Windecker S, Serruys PW. Biolimus-eluting biodegradable polymer versus sirolimus-eluting permanent polymer stent performance in long lesions: results from the LEADERS multicentre trial substudy. EuroIntervention. 2009 Aug;5(3):310-7. (IF: n.d.)
 
Walther T, Falk V, Borger MA, Kempfert J, Ender J, Linke A, Schuler G, Mohr FW. Transapical aortic valve implantation in patients requiring redo surgery. Eur J Cardiothorac Surg. 2009 Aug;36(2):231-4; discussion 234-5. doi: 10.1016/j.ejcts.2009.02.016. (IF: 2.397)
 
Fassl J, Walther T, Groesdonk HV, Kempfert J, Borger MA, Scholz M, Mukherjee C, Linke A, Schuler G, Mohr FW, Ender J. Anesthesia management for transapical transcatheter aortic valve implantation: a case series. J Cardiothorac Vasc Anesth. 2009 Jun;23(3):286-91. doi: 10.1053/j.jvca.2008.12.026. Epub 2009 (IF: 1.062)
 
Falk V, Schwammenthal EE, Kempfert J, Linke A, Schuler G, Mohr FW, Walther T. New anatomically oriented transapical aortic valve implantation. Ann Thorac Surg. 2009 Mar;87(3):925-6. doi: 10.1016/j.athoracsur.2008.12.026. (IF: 3.644)
 
Lenk K, Schur R, Linke A, Erbs S, Matsumoto Y, Adams V, Schuler G. Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model. Eur J Heart Fail. 2009 Apr;11(4):342-8. doi: 10.1093/eurjhf/hfp020. (IF: 3.706)
 
Piazza N, Grube E, Gerckens U, den Heijer P, Linke A, Luha O, Ramondo A, Ussia G, Wenaweser P, Windecker S, Laborde JC, de Jaegere P, Serruys PW. Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval. EuroIntervention. 2008 Aug;4(2):242-9. (IF: n.d.)
 
Walther T, Dewey T, Borger MA, Kempfert J, Linke A, Becht R, Falk V, Schuler G, Mohr FW, Mack M. Transapical aortic valve implantation: step by step. Ann Thorac Surg. 2009 Jan;87(1):276-83. doi: 10.1016/j.athoracsur.2008.08.017. (IF: 3.644)
 
Matsumoto Y, Adams V, Walther C, Kleinecke C, Brugger P, Linke A, Walther T, Mohr FW, Schuler G. Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair. Eur Heart J. 2009 Feb;30(3):346-55. doi: 10.1093/eurheartj/ehn501. (IF: 9.800)
 
Adams V, Mangner N, Gasch A, Krohne C, Gielen S, Hirner S, Thierse HJ, Witt CC, Linke A, Schuler G, Labeit S. Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice. J Mol Biol. 2008 Dec 5;384(1):48-59. doi: 10.1016/j.jmb.2008.08.087. (IF: 4.146)
 
Windecker S, Serruys PW, Wandel S, Buszman P, Trznadel S, Linke A, Lenk K, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, Davies S, van Geuns RJ, Eerdmans P, van Es GA, Meier B, Jüni P. Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): a randomised non-inferiority trial. Lancet. 2008 Sep 27;372(9644):1163-73. doi: 10.1016/S0140-6736(08)61244-1. (IF: 28.409)
 
Adams V, Linke A, Breuckmann F, Leineweber K, Erbs S, Kränkel N, Bröcker-Preuss M, Woitek F, Erbel R, Heusch G, Hambrecht R, Schuler G, Möhlenkamp S. Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners. Eur J Cardiovasc Prev Rehabil. 2008 Oct;15(5):602-7. doi: 10.1097/HJR.0b013e328309c756. (IF: 2.361)
 
Thiele H, Schuster A, Erbs S, Linke A, Lenk K, Adams V, Hambrecht R, Schuler G. Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions. Int J Cardiol. 2009 Jul 10;135(3):287-95. doi: 10.1016/j.ijcard.2008.03.055. (IF: 3.469)
 
Kempfert J, Blumenstein JM, Borger MA, Linke A, Lehmann S, Pritzwald-Stegmann P, Chu MW, Schuler G, Falk V, Mohr FW, Walther T. Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement. Eur Heart J. 2008 Oct;29(19):2382-7. doi: 10.1093/eurheartj/ehn285. (IF: 8.917)
 
Thiele H, Schindler K, Friedenberger J, Eitel I, Fürnau G, Grebe E, Erbs S, Linke A, Möbius-Winkler S, Kivelitz D, Schuler G. Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV versus IC in ST-elevation myocardial infarction trial. Circulation. 2008 Jul 1;118(1):49-57. doi: 10.1161/CIRCULATIONAHA.107.747642 (IF: 14.595)
 
Adams V, Linke A, Gielen S, Erbs S, Hambrecht R, Schuler G. Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training. Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):293-9. doi: 10.1097/HJR.0b013e3282f3ec43. (IF: 2.361)
 
Oberbach A, Lehmann S, Kirsch K, Krist J, Sonnabend M, Linke A, Tönjes A, Stumvoll M, Blüher M, Kovacs P. Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene. Eur J Endocrinol. 2008 Aug;159(2):129-36. doi: 10.1530/EJE-08-0220. (IF: 3.791)
 
Fritzsche K, Blüher M, Schering S, Buchwalow IB, Kern M, Linke A, Oberbach A, Adams V, Punkt K. Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes. Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):606-13. doi: 10.1055/s-2008-1073126. (IF: n.d.)
 
Walther C, Möbius-Winkler S, Linke A, Bruegel M, Thiery J, Schuler G, Halbrecht R. Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):107-12. doi: 10.1097/HJR.0b013e3282f29aa6. (IF: 2.361)
 
Kralisch S, Sommer G, Deckert CM, Linke A, Bluher M, Stumvoll M, Fasshauer M. Adipokines in diabetes and cardiovascular diseases. Minerva Endocrinol. 2007 Sep;32(3):161-71. (IF: n.d.)
 
Erbs S, Linke A, Schächinger V, Assmus B, Thiele H, Diederich KW, Hoffmann C, Dimmeler S, Tonn T, Hambrecht R, Zeiher AM, Schuler G. Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation. 2007 Jul 24;116(4):366-74. (IF: 12.755)
 
Grube E, Schuler G, Buellesfeld L, Gerckens U, Linke A, Wenaweser P, Sauren B, Mohr FW, Walther T, Zickmann B, Iversen S, Felderhoff T, Cartier R, Bonan R. Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcome. J Am Coll Cardiol. 2007 Jul 3;50(1):69-76. (IF: 11.054)
 
Thiele H, Kappl MJ, Linke A, Erbs S, Boudriot E, Lembcke A, Kivelitz D, Schuler G. Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging. Eur Heart J. 2007 Jun;28(12):1433-9. (IF: 7.924)
 
Adams V, Linke A, Wisloff U, Döring C, Erbs S, Kränkel N, Witt CC, Labeit S, Müller-Werdan U, Schuler G, Hambrecht R. Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. Cardiovasc Res. 2007 Jan 1;73(1):120-9. (IF: 6.127)
 
Erbs S, Möbius-Winkler S, Linke A, Adams V, Doll N, Gielen S, Gummert JF, Mohr FW, Schuler G, Hambrecht R. Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):826-31. (IF: 1.979)
 
Erbs S, Linke A, Hambrecht R. Effects of exercise training on mortality in patients with coronary heart disease. Coron Artery Dis. 2006 May;17(3):219-25. Review. PubMed PMID: 16728870. (IF: 1.507)
 
Erbs S, Linke A, Schuler G, Hambrecht R. Intracoronary administration of circulating blood-derived progenitor cells after recanalization of chronic coronary artery occlusion improves endothelial function. Circ Res. 2006 Mar 17;98(5):e48. (IF: 9.854)
 
Ferrarini M, Arsic N, Recchia FA, Zentilin L, Zacchigna S, Xu X, Linke A, Giacca M, Hintze TH. Adeno-associated virus-mediated transduction of VEGF165 improves cardiac tissue viability and functional recovery after permanent coronary occlusion in conscious dogs. Circ Res. 2006 Apr 14;98(7):954-61 (IF: 9.854)
 
Erbs S, Linke A, Adams V, Lenk K, Thiele H, Diederich KW, Emmrich F, Kluge R, Kendziorra K, Sabri O, Schuler G, Hambrecht R. Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study. Circ Res. 2005 Oct 14;97(8):756-62. (IF: 9.408)
 
Hambrecht R, Schulze PC, Gielen S, Linke A, Möbius-Winkler S, Erbs S, Kratzsch J, Schubert A, Adams V, Schuler G. Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2005 Aug;12(4):401-6. (IF: 2.333)
 
Gielen S, Adams V, Linke A, Erbs S, Möbius-Winkler S, Schubert A, Schuler G, Hambrecht R. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil. 2005 Aug;12(4):393-400. (IF: 2.333)
 
Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N, Lenz D, Erbs S, Scheinert D, Mohr FW, Schuler G, Hambrecht R. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation. 2005 Jun 28;111(25):3391-9. (IF: 11.632)
 
Lionetti V, Linke A, Chandler MP, Young ME, Penn MS, Gupte S, d'Agostino C, Hintze TH, Stanley WC, Recchia FA. Carnitine palmitoyl transferase-I inhibitionprevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res. 2005 Jun 1;66(3):454-61. (IF: 5.289)
 
Lenk K, Adams V, Lurz P, Erbs S, Linke A, Gielen S, Schmidt A, Scheinert D, Biamino G, Emmrich F, Schuler G, Hambrecht R. Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia. Eur Heart J. 2005 Sep;26(18):1903-9. (IF: 7.341)
 
Hambrecht R, Erbs S, Linke A, Gielen S. [Physical exercise in older patients with chronic heart failure]. Dtsch Med Wochenschr. 2005 Mar 24;130(12):710-6. Review. German. (IF: 0.653)
 
Adams V, Linke A, Kränkel N, Erbs S, Gielen S, Möbius-Winkler S, Gummert JF, Mohr FW, Schuler G, Hambrecht R. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation. 2005 Feb 8;111(5):555-62. (IF: 11.632)
 
Kränkel N, Adams V, Linke A, Gielen S, Erbs S, Lenk K, Schuler G, Hambrecht R. Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells. Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):698-703. (IF: 7.053)
 
Schulze PC, Linke A, Schoene N, Winkler SM, Adams V, Conradi S, Busse M, Schuler G, Hambrecht R. Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2004 Apr;11(2):155-61. (IF: 3.000)
 
Hambrecht R, Walther C, Möbius-Winkler S, Gielen S, Linke A, Conradi K, Erbs S, Kluge R, Kendziorra K, Sabri O, Sick P, Schuler G. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004 Mar 23;109(11):1371-8. (IF: 12.563)
 
Adams V, Lenk K, Linke A, Lenz D, Erbs S, Sandri M, Tarnok A, Gielen S, Emmrich F, Schuler G, Hambrecht R. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):684-90. (IF: 7.432)
 
Erbs S, Linke A, Gielen S, Fiehn E, Walther C, Yu J, Adams V, Schuler G, Hambrecht R. Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial. Eur J Cardiovasc Prev Rehabil. 2003 Oct;10(5):336-44 (IF: n.d.)
 
Kränkel N, Adams V, Gielen S, Linke A, Erbs S, Schuler G, Hambrecht R. Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression. Mol Genet Metab. 2003 Sep-Oct;80(1-2):262-71. (IF: 2.038)
 
Adams V, Späte U, Kränkel N, Schulze PC, Linke A, Schuler G, Hambrecht R. Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase. Eur J Cardiovasc Prev Rehabil. 2003 Aug;10(4):273-7 (IF: n.d.)
 
Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, Kempf W, Schubert A, Schuler G, Hambrecht R. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003 Sep 3;42(5):861-8. (IF: 7.599)
 
Zhao G, Linke A, Xu X, Ochoa M, Belloni F, Belardinelli L, Hintze TH. Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs. J Pharmacol Exp Ther. 2003 Oct;307(1):182-9. (IF: 4.337)
 
Adler A, Messina E, Sherman B, Wang Z, Huang H, Linke A, Hintze TH. NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats. Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1015-22. (IF: 3.658)
 
Linke A, Zhao G, Recchia FA, Williams J, Xu X, Hintze TH. Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes. Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1007-14. (IF: 3.658)
 
Erbs S, Baither Y, Linke A, Adams V, Shu Y, Lenk K, Gielen S, Dilz R, Schuler G, Hambrecht R. Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1814-9 (IF: 6.791)
 
Erbs S, Gielen S, Linke A, Möbius-Winkler S, Adams V, Baither Y, Schuler G, Hambrecht R. Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy. Am Heart J. 2003 Aug;146(2):280-5. (IF: 3.300)
 
Schulze PC, Gielen S, Adams V, Linke A, Möbius-Winkler S, Erbs S, Kratzsch J, Hambrecht R, Schuler G. Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure. Basic Res Cardiol. 2003 Jul;98(4):267-74. (IF: 2.993)
 
Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 2003 Jul 1;107(25):3152-8. (IF: 11.164)
 
Schulze PC, Kratzsch J, Linke A, Schoene N, Adams V, Gielen S, Erbs S, Moebius-Winkler S, Schuler G. Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Heart Fail. 2003 Jan;5(1):33-40. (IF: 2.983)
 
Gielen S, Erbs S, Linke A, Möbius-Winkler S, Schuler G, Hambrecht R. Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion. Am Heart J. 2003 Jan;145(1):E3. (IF: 3.300)
 
Osorio JC, Stanley WC, Linke A, Castellari M, Diep QN, Panchal AR, Hintze TH, Lopaschuk GD, Recchia FA. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation. 2002 Jul 30;106(5):606-12. (IF: 10.255)
 
Adams V, Nehrhoff B, Späte U, Linke A, Schulze PC, Baur A, Gielen S, Hambrecht R, Schuler G. Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res. 2002 Apr;54(1):95-104. (IF: 4.698)
 
Hambrecht R, Schulze PC, Gielen S, Linke A, Möbius-Winkler S, Yu J, Kratzsch J Jü, Baldauf G, Busse MW, Schubert A, Adams V, Schuler G. Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure. J Am Coll Cardiol. 2002 Apr 3;39(7):1175-81. (IF: 6.278)
 
Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C, Schoene N, Schuler G. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. JAMA. 2000 Jun 21;283(23):3095-101. (IF: 15.402)
 
Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med. 2000 Feb 17;342(7):454-60. (IF: 29.512)
 
Reichardt P, Handrick W, Linke A, Schille R, Kiess W. Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment--a retrospective analysis in 38 children with cystic fibrosis. Infection. 1999 Nov-Dec;27(6):355-6. (IF: n.d.)
 
Adams V, Jiang H, Yu J, Möbius-Winkler S, Fiehn E, Linke A, Weigl C, Schuler G, Hambrecht R. Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. J Am Coll Cardiol. 1999 Mar 15;33(4):959-65. (IF: 2.171)
 
Hambrecht R, Adams V, Gielen S, Linke A, Möbius-Winkler S, Yu J, Niebauer J, Jiang H, Fiehn E, Schuler G. Exercise intolerance in patients with chronic heart failure and increased expression of inducible nitric oxide synthase in the skeletal muscle. J Am Coll Cardiol. 1999 Jan;33(1):174-9. (IF: 7.368)
 
Punkt K, Adams V, Linke A, Welt K. The correlation of cytophotometrically and biochemically measured enzyme activities: changes in the myocardium of diabetic and hypoxic diabetic rats, with and without Ginkgo biloba extract treatment. Acta Histochem. 1997 Aug;99(3):291-9. (IF: n.d.)
 
Adams V, Yu J, Möbius-Winkler S, Linke A, Weigl C, Hilbrich L, Schuler G, Hambrecht R. Increased inducible nitric oxide synthase in skeletal muscle biopsies from patients with chronic heart failure. Biochem Mol Med. 1997 Aug;61(2):152-60. (IF: 2.171)
 
Bowen TS*, Mangner N*, Werner S, Glaser S, Kullnick Y, Schrepper A, Doenst T, Oberbach A, Linke A, Steil L, Schuler G, Adams V: Diaphragm muscle weakness in mice is early-onset post myocardial infarction and associated with elevated protein oxidation. J Appl Physiol 2014. *shared first author ship
 
Mangner N, Scheuermann K, Winzer E, Wagner I, Hoellriegel R, Sandri M, Zimmer M, Mende M, Linke A, Kiess W, Schuler G, Körner A, Erbs S: Childhood Obesity – Impact on Cardiac Geometry and Function. JACC Cardiovasc Imaging. 2014 Dec;7(12):1198-205.
 
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Universitätsklinik für Kardiologie / Axel Linke
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Universitätsklinik für Kardiologie